To evaluate efficacy and safety of Xuezhikang Capsule in Treating fatty liver. Methods: A total of 198 patients were randomly divided into 2 groups. The treatment group (n=99) received Xuezhikang Capsules po bid in addition to diet and exercise control， and control group (n=99) only received diet and exercise control， for a course of 12 weeks. Results: Of the treatment group， the response rate was 47%， effective rate was 45%， total effective rate was 92%， compared with respectively 20%， 24%， 44% of the control group (P<0.01). Conclusion: Xuezhikang Capsules is effective and safe to treat fatty liver， significantly lowers blood lipids and improves liver function， so as to prevent Liver fibrosis and hepatic cirrhosis. With competitive cost， Xuezhikang Capsules is suitable for clinical application.