To observe the clinical effects of Danhong injection combined with alprostadil injection on ischemic cerebrovascular disease.Methods:One hundred cases of ischemic cerebrovascular disease were randomly divided into treatment group and control group respectively. Alprostadil injection was used for the control group，while Danhong injection combined with alprostadil injection was used for the treatment group. The neurological deficit and improving life skills scores were compared between the two groups before and after treatment.Results:The clinical efficacy in treatment group was better than control group (P<0.05). Neurological deficit and improving life skills scores in treatment group were higher than that in the control group (P<0.05). Conclusion:It has an obvious effect treating ischemic cerebrovascular disease with Danhong injection combined with alprostadil injection.