To investigate pharmacodynamic effect of Sizi Zhongwang Capsule in order to provide theoretical basis for clinical application. Methods: Four experiments with rats were carried out separately. The infleuces on rats' fertility， weight of reproductive organs， anti-fatigue capability and survival capability at low temperature were observed. Results:The following was observed: obvious increase of semen in contorted seminiferous tubules， increased pregnancy rate of female rats， improvement of functions of preputial gland， samenblase and prostate in castrated rats， swimming time increase in yang deficient mice， improved survival rate of yang deficient mice at low temperature. Conclusion:Sizi Zhongwang Capsule can significantly increase survival rate and number of semen.