High laboratory indicators of endocrine diseases refers to high blood sugar，high blood pressure，high cholesterol，high weight，high uric acid，high microalbuminuria and proteinuria，which is a group of interrelated metabolic risk factors combination. We believe that normal people is a circular motion of five elements，Tu-qi in the central is an axis; Mu-qi in the east，Huo-qi in the south，Jin-qi in the west，Shui-qi in the north，which are the four wheels. The body will maintain good health as long as the circular motion in the ordered state，otherwise disease will occur. Based on the circular motion of five elements，the pathogenesis of the high laboratory indicators is mainly excessive Mu-qi in the east to disperse，failure of Tu-qi in the central to transport and transform，failure of Shui-qi in the north to warm and reinforce. In clinical practice，reconciling Mu-qi in the east，transporting and transforming Tu-qi in the central，warming and reinforcing Shui-qi in the north，is the main therapeutic principle; commonly used medicine include Mume Pill， Decoction of Evodia，Bolus for the Function of Middle Energizer，Decoction for Resuscitation. In conclusion, we must understand the theories of Yin-yang and five elements, and its motions in order to understand and treat various disease.