To observe efficacy of Shengshitong granule combined with percutaneous nephrolithotomy using Holmium laser for treatment of kidney stones.Methods:Thirty-four patients with multiple kidney stones were treated by Shengshitong granule combined with percutaneous nephrolithotomy using Holmium laser. We evaluated the treatment effect after 3 months by B-mode ultrasound and KUB plain film.Results:In treatment group of 34 cases，33 cases were without residual stones，the curative rate was 97.1% in 3-month follow-up. The curative rate of control group (32 patients performed surgery only) was 78%. The efficacy of treatment group was significantly better than that of the control group.Conclusion:Shengshitong granule combined with percutaneous nephrolithotomy by Holmium laser was safe and effective for the treatment of kidney stones.