To observe effect of Chinese Medicine combined with Ursodeoxvcholic acid (UDCA) on liver functions and lipids of patients with primary biliary cirrhosis. Methods:Sixty patients were randomized to 2 groups, taken respectively Chinese Medicine combined with UDCA, or UDCA only for 2 months. After 2 months, efficacy was compared between the two groups. Results:Total effective rate was 47% of treatment group, compared with 31% of control group (P<0.05). After treatment, patients in both groups had seen lower levels of lipids (CHO、TG) and liver function related parameters (ALB、ALT、GGT、TBil、ALP), improvement was more significant in control group. Conclusion:Chinese Medicine combined with UDCA is effective to treat primary biliary cirrhosis, lower lipid levels and improve liver functions.