To observe effect of Jianpi Xiaoji Decoction on life quality of patients with cancer-related fatigue. Methods:Sixty-two patients were randomized to treatment group (n=32) and control group (n=30), both groups received radiotherapy for 2 treatment periods, 21 days per period. The control group took Jianpi Xiaoji Decoction for the same treatment period. After treatment, EORTC-QLQ-SF-36 was used to evaluate fatigue conditions and adverse event was collected. Results:According to EORTC-QLQ-SF-3, the treatment group was better than control group in terms of physical function, role identification, emotions, signs and symptoms and overall conditions (P<0.05). Two group was not statistically different in terms of cognitive functions and social function (P>0.05). And treatment presented less adverse event (P<0.05). Conclusion:Jianpi Xiaoji Decoction can improve immunity functions, relieve clinical symptoms and fatigue condition, improve life quality and extend survival time.