To study the regulation effect of Bupi Qufeng Decoction on ECP and Th1/Th2 cell in atopic dermatitis (AD) patients.Methods:A total of 101 cases of chosen medical records were randomly divided into treatment group and control group according to digital table. During the treatment, both groups were given compound Danggui Bohe paste for external use. Based on this，the treatment group was given Bupi Qufeng Decoction orally, while the control group was given loratadine orally. ECP、IFN-γand IL-4 count were determined before the treatment and four weeks after the treatment, and Thl and Th2 cells were detected by IFN-γ and IL-4.Results:After the treatment，the level of ECP in the treatment group decreased significantly (t＝18.57，P<0.001), and the decrease range was greater than the control group (t＝15.22，P<0.001); the level of Th1 in treatment group significantly increased (t＝3.34，P<0.01), and the increase range was greater than the control group(t＝2.20，P<0.05); the level of Th2 in treatment group significantly reduced(t＝11.87，P<0.001), and the reduction was greater than the control group(t＝1.99，P<0.05); the value of Th1 / Th2 in treatment group increased significantly (t＝4.07，P<0.001), and the increase range was more than the control group (t＝4.64，P<0.001).Conclusion:Treating spleen deficiency type of atopic dermatitis with Bupi Qufeng Decoction can effectively reduce serum ECP and adjust Th1 / Th2 balance. Bupi Qufeng Decoction has better effect than loratadine.