To observe efficacy of integrative Chinese and western treatments with Yingping series as the principle medicine, for treatment of ankylosing spondylitis. Methods: 105 patients were treated by the Chinese medicine, formulated based on syndrome differentiation, plus blood therapeutics, calcium therapeutics and immunotherapy. Results: 70 patients showed significantly improvements (66.67%), 25 patients were effectively treated (23.81%), total effective rate reached 90%. Conclusion: The Chinese medicine characterized by syndrome differentiation is in line with the therapeutic principle of Chinese medicine. Integrative treatment of Chinese and western medicines has superior efficacy than single use of each medicine.