To observe the effect of the Chen Yi-ping’s empirical formula：Qi-Tonifying Kidney-Replenishing Dampness-Eliminating and Turbid-Dispersing Formula in treatment of gouty nephropathy.Methods:The GN patients were randomly divided into treatment group(35 cases) and control group(24 cases).In addition to routine treatment, the controlled group was given Allopurinol; and the treatment group was given Allopurinol and the formula. We observed the changes of the correlated parameters after 6 months of treatment.Results:After treatment, the UA levels dropped in both groups; the treatment group with a wider reduction margin than the control group.The SCr levels of treatment group also dropped after treatment, while it didn’t significantly changed in control group.Conclusion:Qi-Tonifying Kidney-Replenishing Dampness-Eliminating and Turbid-Dispersing Formula combined with Allopurinol can decrease SCr and UA, and better protect kidney functions than using Allopurinol alone.