To observe the effect of Tianwang Buxin Bolus on anxiety disorders with insomnia for the main symptoms, and to compare with the effect of Western medicine.Methods: A total of 80 patients were randomly divided into treatment group (n=41) and control group(n=39). The treatment group were treated with Tianwang Buxin Bolus, while the control group were given lorazepam. The effect and the side effect of the two groups were compared. Results: Both of the two methods can improve insomnia. The improvement of other anxiety symptoms in treatment group is obvious, and side effects is less than that of the control group (P﹤0.05).Conclusion:Tianwang Buxin Bolus has obvious effect on improving anxiety disorders with insomnia for the main symptoms.