Tripterygium wilfordii has a great application prospect in immunological diseases, nerve protection and tumor control, but the toxicity limits its application. Based on textual research of Tripterygium wilfordii, alias, source of production, and attenuated measures were identified, providing herbalist basis for development of resource-related varieties. Methods:Analyzed description of Tripterygium wilfordii from the ancient herbal books and local herbal books of past dynasties. Results:First records about Tripterygium wilfordii started from herbal books in Qing Dynasty. The information about compatibility can provide guidance for attenuation.