Fascia connective tissue almost exists in all body tissues， organs and systems. When many of diseases developed into the multi-functional failure， connective tissue will be inevitably affected to lead the disorder of multi-system. It was reported that almost 1/5 patients’ sufferings were related to fascia in an international epidemiological study. If the pain was relieved firstly， the clinical therapeutic effect will be greatly improved. In this paper， the “resonance theory” and “principle of reducing tension to relieve pain” for surgical knotty diseases were innovatively proposed， and resolving the disorders of connective tissue tension to relieve the pain was been recommended. The research of the fascia theory could provide scientific basis for the diagnosis and treatment of the surgical knotty diseases.