To investigate the clinical effectiveness of Xuebijing injection on septic patients. Methods:Forty patients were randomized to control group (n=20) and xuebijing group (n=20). Both groups were treated according to 2008 sepsis guideline. Xuebijing group added xuebijing 100mL + 0.9% NS 100mL， bid， 7days for one period. Body temperature was monitored and 3ml blood was collected before treatment， 3days and 7days after treatment and stored in -80℃. TNF-α， IL-8 and CRP were determined by the method of ELISA and immunoturbidimetry.Conclusion:Xuebijing injection can degrade inflammatory cytokines， improve sepsis prognosis， and reduce the length of ICU stay， so the expense of hospitalization can be decreased.