We observed the effect of Chinese medicine， given as a result of syndrome differentiation， on the progress-free survival and life quality of patients with triple negative breast cancer (TNBC) as well as the strategy of traditional Chinese Medicine. Method: 101 patients at stage II/IIII/IV were divided into two cohorts， of which 65 cases were treated with combination of herbs and standard western medicine and 36 cases by the western medicine alone. Progress-free survival and symptoms like numbness and chemo-brain were evaluated. Results:During 36-month follow-up， there was a statistically significance in DFS by Kaplan-meier although no significance in DFS by COX， and there were significances in improvement of numbness and chemo-brain in combination. Conclusion:Chinese medicine treatment according to syndrome differentiation， may be beneficial to patients with TNBC， the efficacy needs to be further proved on a larger number of patients. Chinese medicine can improve quality of life by relieving the symptoms such as numbness and chemo brain caused by chemotherapy.