Shengsanzi prescription was mainly used for the treatment of cold-dampness pestilence. Su Dongpo used it to treat pestilence in Song Dynasty and saved many patients’ lives. He then wrote a book to spread the theory， after which， Shengsanzi prescription was popular in treatment. However， this same prescription had reverse effects in following dynasties. It was said that many patients had been killed by it in the following dynasties. So it was gradually abandoned. Fortunately， Shengsanzi prescription did not quit the stage of history in this regard but gained new life with the help of Yunqi theory.