To explore the therapeutic effect of CT guided percutaneous pneumocentesis perfusion combined with lifei tablet in treating cavernous multi drug resistant pulmonary tuberculosis.Methods:Eighty four patients suffered from cavernous multi drug resistant pulmonary tuberculosis were randomly divided into two groups. Patients in treatment group received gel perfusion containing antitubercular drugs through CT guided percutaneous pneumocentesis, as well as general chemotherapy and lifei tablet. Patients in control group were only given antitubercular drugs.Results:The sputum negative conversion rate was 73.3%,foci absorption rate was 71.1%,and cavity closure rate was 47.4% in the treatment group,all of which were higher than those of the control group. There were significant differences between the two groups.Conclusion:CT guided percutaneous pneumocentesis perfusion combined with chemotherapy and lifei tablet showed better therapeutic effect than chemotherapy in treating cavernous multi drug resistant pulmonary tuberculosis with safe procedure and few side effects.