To observe the clinical effect of Tongqiao Huoxue decoction for acute cerebral infarction.Methods:A total of 56 cases were randomly divided into treatment group and control group, 28 cases in each group. The two groups were both given conventional treatment. The treatment group was given Tongqiao Huoxue decoction; while the control group was given Shuxuetong injection. NIHSS, hemorheology and high sensitivity C reactive protein (hs CRP) were compared after 15 days.Results:The total effective rate of treatment group was 96.4%, which was significantly higher than that of control group (71.4%)(P<005). NIHSS, hemorheology and hs CRP of the two groups were significantly improved after treatment, and treatment group was more significant than control group(P<005).Conclusion:Tongqiao Huoxue decoction has obvious therapeutic effect for acute cerebral infarction. It can improve hemorheology and reduce hs CRP level, and is worthy of clinical use.