To observe the influence of CEJS on CyclinD1,and CD44 expression in Lewis lung carcinoma tissues in mice, so as to explore its anti tumor mechanism.Methods:Murine models were transplanted with LLC cell, which were prepared and divided into a model group and five other groups of CTX, CEJS(medium dose), low, medium and high dose CEJS joint CTX prescription. Then the tissues of the six groups were separated for immuno histochemical examination of CyclinD1 and CD44.We observed the life period for two months at the same time .Results:CEJS (medium dose) and high dose CEJS joint CTX prescription resulted in more significant suppression of the expression of CyclinD1(P<005)when compared with the model group. Moreover, the expression of CD44 in every group except the low dose CEJS joint CTX prescription was lower than that in the model group(P<005).The relation of CyclinD1 and CD44 wasn’t approximately linearity(r=0.232 21,P>005).CEJS (medium dose) group has a trend to prolong the life period.Conclusion:Inhibition of the growth of Lewis Lung Carcinoma by CEJS prescription is probably related to its suppressive impact on the expression of CyclinD1 and CD44.It could intervene in the cell cycle, retard the aggression of tumor and maybe improve the prognosis.