To optimize emulsification of starch sodium octenyl succinate (SSOS) Zedoary oil by application of response surface analysis.Methods:High performance liquid chromatography (HPLC) was used to measure and compare how different substituted ratio, concentration and wall core ratio affect the microencapsulation efficiency of curcumol and β elemene in starch sodium octenyl succinate (SSOS) Zedoary oil, and response surface analysis was used to optimize the emulsification condition.Results:Response surface analysis showed that the most optimized emulsification condition of SSOS was 007 substituted ratio, 005 wall core ratio and 0.17 wall core ratio. The microencapsulation efficiency of curcumol was 10000%, and that ofβ elemene was 34.891%.Conclusion:Response surface analysis is practically instruction for optimizing emulsification of SSOS zedoary oil.