To observe clinical curative effects and safety of three candidate prescriptions of Wendanningxin for treating insomnia, and clarify its active ingredients.Methods:Random control trial was conducted to randomly divide 90 insomnia patients into three groups: YF group, HXF group, and HXJJF group. Treatment courses were four weeks, and clinical curative effects were assessed by PSQI.Results:After 4 weeks’ therapy, all of the three candidate prescriptions showed significant differences in PSQI total scores within each group (P<0.05). The effective rates of the three prescriptions were respectively YF group 55.56%, HXF group 57.14% and HXJJF group 61.54%, without showing significant differences among the three groups (P>0.05).Conclusion:All of three prescriptions show the function of hypnosis, and the therapeutic effects among them are essentially equivalent. HXJJF shows the highest effective rate, which maybe one of the best candidates for prescription optimization.