To observe the clinical curative effect of modified Xuefu Zhuyu Decoction in treating reflux esophagitis (RE) accompanied by depression.Methods:Sixty patients suffered depression RE were randomly divided into treatment group(30 cases)and control group(30 cases). Patients in treatment group were given modified Xuefu Zhuyu Decoction, while the control group treated patients with omeprazole, domperidone, flupentixol and melitracen tablets. Clinical curative effect was evaluated according to the changes of score in clinical symptoms and zung Self Rating Depression Scale(SDS) and observation under gastro scope.Results:Four weeks after treatment, the clinical symptom score and depression points of the treatment group were significantly better than that of the control group (P<0.05); eight weeks after treatment, there were no significant difference between the two groups on the total therapeutic effect (P>0.05). The follow up conducted six month after drug withdrawal showed better total therapeutic effect in treatment group (P<0.05).Conclusion:Modified Xuefu Zhuyu Decoction has instant and satisfactory therapeutic effect along with low recurrence rate in treating reflux esophagitis accompanied by depression.