To Observe clinical effect of Yanfukang suppositouiumin for the treatment of vaginitis. Methods: Patients getting treatment in gynecology outpatient department of our hospital were selected in the study, including 110 cases of bacterial vaginosis, 110 cases of trichomonas vaginitis , and 110 cases of Candida albicans vaginitis. Following the principles of randomization, control and double blind, patients suffered in the three types of vaginitis were respectively divided into treatment group and matrine suppository group with 55 patients in each group. Patients in treatment groups were given Yanfukang suppositouium ,and those in control groups received matrine suppository before bedtime every day. The suppositouiums were slightly placed in the posterior fornix. Patients were given continuous treatment three days after menstruation for three treatment courses with14 days in each treatment period. The total therapeutic effect after treatment were observed and compared. Results: 1) The total therapeutic effect in the treatment group of bacterial vaginosis was 87.0%, and that in the matrine the suppository group was 76.9%. The treatment group showed more satisfactory result than the control group (P<0.05). 2) The total therapeutic effect in the treatment group of Candida albicans vaginitis was 84.9%, and that in the matrine the suppository group was 69.8%. The treatment group showed more satisfactory result than the control group (P<0.05). 3) The total therapeutic effect in the treatment group of trichomonas vaginitis was 83.0%, and that in matrine the suppository group was 71.7%. The treatment group showed more satisfactory result than the control group (P<0.05). Conclusion: Yanfukang Suppositouium applied in treatment of bacterial, Candida albicans, and trichomonas vaginitis showed significant improvement of symptoms, low recurrence rate, and sight side effects which worth clinical generalization.