To investigate the psychological factor influencing clinical therapeutic effects of Electric Acupuncture(EA) in treating Chronic Prostatitis/ pelvic Chronic pain syndromes, and provide a scientific basis for psychotherapy.Methods:Clinical data of 77 CP/CPPS patients and 35 healthy male subjects were collected. The anxiety rate and depression symptom of the two groups were analyzed. The CP/CPPS patients were treated with EA for 4 weeks. Based on the therapeutic results, the influence of psychological factors on the prognosis of CP/CPPS treated with EA was analyzed with univariate and multivariate Cox regression.Results:The rates of anxiety and depression of the CP/CPPS in EA group were 25.974% and 27.273%, higher than those of normal controls (P<0.05). The total effective rate of EA treating with CP/CPPS was 87.012%. The analysis revealed that depression were the definite factor that negatively affected the prognosis of CP /CPPS treated by EA (P<0.05),while anxiety had no significant influence (P>0.05).Conclusion:Depression is the definite factor that negatively affected the prognosis of CP /CPPS treated by EA. Importance should be attached to the psychological factors of CP/CPPS patients and proper psychological intervention is sometimes necessary.