To provide reference for solving the problem on the safety of traditional Chinese medicine injections(TCMI) through exploring the related influential factors.Methods:Relevant literature in recent years were reviewed, and the factors that influenced the safety of traditional Chinese medicine injections were recognized and analyzed.Results:There were factors influencing of the safety of TCMI in aspects covering R&D, manufacture, circulation, and utilization.Conclusion:Based on principle of strengthening supervision for all aspects, we should have rational knowledge on the safety of traditional Chinese medicine injections, to avoid or reduce the occurrence of adverse event of TCMI.