To provide reference to standardized clinical syndrome differentiation of type 2 diabetes with retinopathy (DR) through the study on its syndromes and patterns. Methods:Information and data of 104 patients diagnosed as type 2 diabetes with retinopathy in Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine were gathered, input, and analyzed. Results:The highest appearance frequency of the syndromes in 104 patients were phlegm damp syndrome, blood stasis syndrome, yin deficiency syndrome, qi depression syndrome, damp heat syndrome, and qi deficiency syndrome. The frequency of all the above were over 50%, which indicated that among these samples, yin deficiency and qi deficiency were the main patterns for healthy energy and deficiency; phlegm damp, blood stasis, qi depression and damp heat were the main patterns for tip and root. Conclusion: 1) The condition of DR does not have too much to do with the ages of patients, while it is closely relevant to the length of disease course; 2) Diabetic nephropathy, hypertension, and hyperuricemia are relevant to the onset and development of DR; 3) Multiple syndromes and complex of deficiency and excess were the characteristics of DR; 4) The level of glycolated hemoglobin has positive association with phlegm damp syndrome and damp heat syndrome of DR; the level of urinary albumin has positive association with yang deficiency syndrome and phlegm damp syndrome of DR; hemorrhage and microscopic changes of fundi has positive association with yang deficiency syndrome.