To evaluate the clinical therapeutic effect of Lutein on the treatment of age-related macular degeneration (AMD). Methods:137 eyes of 83 AMD patients were randomized in a controlled, double blind trial. The treatment group was treated with lutein chewable tablets and the control group were treated with placebo. After 3-month treatment, the changes of distant vision and puncta luteum in OCT were observed. Results:The total effective rate of the treatment group was 56.76%, significant better than 30.16% of the control group (P<0.001). Conclusion: Lutein showed therapeutic effect for age-related macular degeneration, such as improving visual activity, elimination of retina edema and atrophying.