To investigate the prevalence rate of anxiety and depression among outpatients in the department of Acupuncture and Moxibustion in a 3A grade general hospital in Beijing. Methods:All the first-visit-outpatients were tested with Zung’s Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS). Outpatients of the group, of whose initial scores ≥40, were tested further with the 17-item Hamilton Depression Scale (HAMD17) and the Hamilton Anxiety Scale(HAMA). And the diagnoses were made according to the 10th edition of International Classification of Disease Criteria (ICD10). Results: Among 325 cases, 106 cases were male and 219 cases were female, disease rate of anxiety and depression disorder accounted for 34.77%, female accounted for 24% and male accounted for10.77% in the category of sex. The Prevalence rate in female is significantly higher than that in male. People who are aged 40 and over accounts for 71.68 % among outpatients screened positive.Conclusion: There is a higher prevalence of anxiety and depression disorder among outpatients in the department of Acupuncture and Moxibustion in general hospital. Most patients are complained of physical malaise which easily resulted in a misdiagnosis, more attention and training on basic knowledge of psychosis should be paid to doctors of department of Acupuncture and Moxibustion, so as to improve their ability of diagnosis and treatment.