In order to study the adaptability to the Pungent-Cool Drugs by the heat urticaria patients, based on the theory of Yin-Yang and the principles of Chinese medication treatment, a clinical comparison research on the adaptability to the pungent-warm and pungent-cool drugs by human body was carried out. Methods:Twenty five commonly used divergent herbs, including 14 pungent-cool and 11 pungent-warm herbs were evaluated in this experiment to test their adaptabilities by human body through quantitative detection on meridian points with bio-resonance technique in a selected Med-test mode. Results:The adaptabilities of the 25 herbs by 37 heat urticaria patients ranged from 8.11% to 45.95%, with the average of 21.51%. And the 9 herbs with highest frequencies are listed as follows: Menta haplocalyx, Lemma polyrhiza L, Schizonepeta, Divaricate Saposhnikovia Root, Feverfew, Rhizoma Cimicifugae, Periostracum Cicadae, Lonicera japonica, Folium mori, mostly Pungent-Cool Drugs. The adaptability to Pungent-Cool Drugs by the heat urticaria patients was higher than the Pungent-Warm ones (P<0.005). Conclusion: The Pungent-Cool Drugs are more suitable to treat heat urticaria than the Pungent-Warm ones. The basic theory of Yin-Yang and the principles of Chinese medication treatment proved to be convincible.