To research and explore Shenwuyishen Tablets, the prescription of Professor Zou Yunxiang, in the clinical use of chronic renal failure (CRF). Methods: Using the methods of a multicenter, randomized, double blind double-dummy, parallel control for positive drug. The curative efficacy of Shenwuyishen Tablets for CRF with Qi and Yin deficiency and dampness syndrome was evaluated. Meanwhile, basic researches for Shenwuyishen Tablets, including pharmacology, pharmacodynamics and molecular cytology, were developed. Results: Shenwuyishen Tablets can significantly improve the CRF with Qi and Yin deficiency and dampness syndrome in clinical manifestations. It lowered BUN and SCr levels, reduced urinary protein loss, increased CCr. The results of the experiment group were better than that of the control group. The mechanism of Shenwuyishen Tablets may be associated with regulating hormone levels in a variety of ways, improving hemodynamics, inhibiting mRNA expression of cell enhancer factor and extracellular matrix components, inducing apoptosis, reducing the damage of glomerular, improving the functions of kidney tubules and tubulointerstitial, thus protecting the renal function and to delay the progression of chronic renal failure.