To discuss the origin and efficacy of Professor Zhang Daning’s application of “ascending lucidity and descending turbidity” in the treatment of renal diseases. Methods: By following Prof. Zhang in clinical practice, listening to his lecture, and referring to ancient and modern literatures, collect cases of chronic renal diseases treated with rhizoma cimicifugae, and observe its efficacy. Results: Prof. Zhang’s application of “ascending lucidity and descending turbidity” effectively reduced urine protein and hematuresis, and enhanced kidney function. Conclusion: Professor Zhang Daning’s application of the theory “ascending lucidity and descending turbidity” has sufficient theoretical grounding and good clinical efficacy.