To explore the effect of Sini decoction on functional constipation patients．Methods:Eighty-two cases of functional constipation patients were randomly divided into treatment group and control group．The control group received lactulose therapy，while the treatment group were given Sini decoction medicine therapy．Both the control group and treatment group received the corresponding treatment for one month and the quality of life and improvement of clinical symptoms were assessed. Results: The total effective rate in treatment group and control group were respectively 81.4% and 56.4%．Significant difference was observed between the two groups (P＜0. 05), and PAC-QOL scale scores after treatment than before treatment decreased with statistical significance．Conclusion: Sini decoction therapy of traditional Chinese medicine is effective in relieving clinical symptoms and enhancing life quality of functional constipation patients.