Objective:To observe efficacy of Chinese medicine combined with ursodeoxycholic acid, energy mixture on intrahepatic cholestasis of pregnancy and improvement of perinatal outcome.Methods:100 patients with ICP were randomly divided into treatment group and control group,within two-week course of treatment patients in the treatment group were treated with Chinese medicine combined with ursodeoxycholic acid, energy mixture, and in the control group only ursodeoxycholic acid and energy mixture were used. After treatment pruritus relief,total bile acids,liver transaminase levels and perinatal outcome of children were observed. Results: Compared with the control group,the level of total bile acid and liver transaminase of treatmetn group declined, the rates of fetal distress, meconium, asphyxia, premature birth were significantly lower (P<0.05).Conclusion:The treatment of Chinese medicine combined withursodeoxycholic acid and energy mixture is effective for treatment of intrahepatic cholestasis of pregnancy.