To investigate the impact of dyspepsia on immune function on influenza virus ( FM1 ) infected mice, through detecting the serum levels of immunoglobulin M (IgM), Interferon-γ(IFN-γ), Interleukin-4(IL-4)and TH1/TH2. Methods:The mice dyspepsia model was built by feeding mice with high protein- calorie food, then nasal infected with FM1 influenza A virus, randomized to normal group, infected group, and infected and dyspepsia group on D3 and D5 after infection, detected the serum level of IgM, IFN- γ, IL-4 and TH1/TH2 levels. Results:Mice were infected with FM1 virus at D5, the IgM level of both infected groups were significantly higher than that of the normal group (P<0.05). The dyspepsia group showed significantly decreased IgM level (P<0.01) compared with the virus infected group; at D1, D3, D5, the serum level of TH1 ( IFN-γ) /TH2 ( IL-4 ) of the infected groups were lower than that of the normal group, and the reduction was siginificant on D3 (P<0.05); at D3 and D5 the dyspepsia group was even more lower (P<0.05). Conclusion: Dyspepsia can break the balance of immune system by impacting IgM, IFN- γ, IL-4 and TH1/TH2, indicating dyspepsia plays a role in influenza epidemic.