After reviewing the mainstream herbal classics on nature, flavour, related indications, and efficacy of Rhizoma Atractylodes Macrocephala, this paper summarized the history and evolution of the nature and flavor of Rhizoma Atractylodes Macrocephala, pointing out its development history of warm-heat nature and bitter,sweet,pungent flavor, and meanwhile analyzed their relations to clinical application. The paper concluded that there were controversial descriptions in ancient classics on the warm-heat nature of Rhizoma Atractylodes Macrocephala, as well as the mentioning of pungent flavor which were different from the modern pharmacopeias and needed further experimental evidence.