To study the clinical efficacy of berberine hydrochloride combined with metformin for treatment of type 2 diabetes mellitus(T2DM) with hyperlipidemia. Methods: Fifty three cases T2DM patients with hyperlipidemia were assigned to treatment group (n=27) and control group (n=26). All the patients were treated with Metformin Hydrochloride Enteric-coated Tablets(MHET). And the treatment group were simultaneously given berberine hydrochloride. Changes of blood glucose, blood lipid and body mass index(BMI) after 2 months of treatment were compared between the two groups. Results: The blood glucose, blood lipid and BMI of patients in the treatment group were better improved compared with the control group. There was significant difference between the two groups(P<0.05). Conclusion: Berberine hydrochloride combined with metformin for treatment of type 2 diabetes mellitus and hyperlipidemia has definite therapeutic effect on reducing blood glucose, decreasing BMI and improving hyperlipidemia.