To study the therapeutic effect of compound danshen dripping pills combined with isosorbide mononitrate tablets treating patients with angina pectoris. Methods: One hundred and seven patients with angina pectoris were randomly divided into observation group (n=53) and control group (n=54). Patients in observation group were given compound danshen dripping pills and isosorbide mononitrate tablets. The control group gave patients isosorbide mononitrate tablets only. After 4 weeks, the clinical symptoms, electrocardiogram and blood rheology changes of the patients were comparatively analyzed between two groups. Results: The effective rate of relieving angina pectoris in the observation group and the control group were respectively 83.02% and 53.70%, which showed significant differences between the two groups (P<0.05). The effective rate of electrocardiogram in the observation group and the control group were respectively 77.36% and 48.15%, which showed significant differences between the two groups (P<0.05). After treatment, hemorheology of patients had ameliorated significantly in the observation group (P<0.05). Hemorheology of patients after treatment in the control group also decresed, however, there were no statistically significant differences (P>0.05). Conclusion: Compound danshen dripping pills combined with isosorbide mononitrate tablets treating angina pectoris shows definite therapeutic effect in relieving angina pectoris symptoms, improving ECG and decreasing blood viscosity