To observe the different curative effects of hemoperfusion combined with hemodialysis (HDP) therapy treating patients with uremic cutaneous pruritus with different syndromes. Methods: According to the syndrome scale, fifty eight cases of uremia patients with intractable pruritus were divided into inside stasis of wet poison group, and blood deficiency generating wind group. Patients were given hemoperfusion combined with hemodialysis therapy, four to eight times a month, for eight weeks. Pruritus score before and after treatment and cationic serum levels such as serum segment parathyroid hormone (iPTH) and phosphorus, magnesium etc were measured in each group. Results:After treatment, prutitus were obviously relieved on patients in both groups, especially for blood deficiency generating wind group, and the curative effect was statistically different from that of the inside stasis of wet poison group. Conclusion:Hemoperfusion combined with hemodialysis can effectively improve patients’ pruritus symptoms, and curative effect is different among different syndromes. These results can provide reference for further biological markers of TCM syndromes and the clinical treatments.