To evaluate the efficacy and side reactions of Traditional Chinese Medicine along with target in target radiation therapy in patients with inoperable advanced pancreatic cancer. Methods: Retrospective analysis was given to 42 patients with inoperable advanced pancreatic cancer admitted to our hospital from October 2000 to December 2012. Patients were treated with Kangai injection and three-dimensional conformal radiation therapy (3D-CRT) or Intensity-modulated radiation therapy (IMRT). Low-speed computed tomography simulation was conducted. Among these, thirteen patients received concurrent chemotherapy and modified Wu Mei Wan. Results: The complete response rate (CR) and the partial response rate (PR) in the primary tumors were 28.6% and 47.6%, and the overall response rate (CR+PR) was 76.2%. The median survival time (MST) and 1-year overall survival rate (OS) was 14.8 months and51.7%. Concurrent chemoradiotherapy tended to improve overall survival (P=0.089). After treatment, 31 patients had clinical benefit response, mainly abdominal pain relief. Conclusion: Kangai injection and target in target radiation therapy is effective in alleviation of disease-related symptoms in patients with inoperable pancreatic cancer, though concurrent chemoradiotherapy with Wu Mei Wan confers a trend of survival improvement over sole radiotherapy.