To explore the clinical curative effect of TCM preventing and treating outbreak of epidemic mumps. Methods: Two locations were randomly selected which out broke epidemic mumps. Patients were divided into a control group and a observation group. The 41 patients in the control group and 213 high-risk susceptible people were given western medicine to treat and prevent. The 49 patients in observation group and 283 cases of high-risk susceptible people received TCM treatment and prevention. The therapeutic effects and preventive effects in both groups were observed. Results: After one treatment course, the total effective rates in both groups were 100%. The curative rate in observation group was 87.76%, which was significantly better than that of the control group (60.98%). After treatment, TCM symptom scores of observation group decreased more obviously (0.58 ± 0.17) than the control group (2.17 ± 0.33). The time it took to start decreasing fever, bring down fever completely, subside one thirds of swelling of steno’s gland and totally subside swelling of steno’s gland in the treatment group were obviously shorter than those of the control group. The successful preventive rates in observation group and control group were respectively 100% and 94.84%, which showed statistically significant difference (P<0.05). Conclusion: TCM may prevent the incidence of epidemic mumps among high-risk susceptible people, it can quickly relieve the patient's condition, alleviate patients’ pain, shorten disease course with satisfactory therapeutic effect. It is worth clinical application.