To observe the clinical effect of the therapy of mental intervention and acupuncture for the stroke patients with dysthymic disorder. Methods: After assessing SDS and SAS, 40 stroke patients with dysthymic disorder who met the criteria were selected and randomly divided to two groups, all were given conventional treatment first. On the basis of evaluation form of Barthel which aimed to judge the ability of ADL, the degrees of functional defects were affirmed. Patients in the treatment group were given mental intervention and acupuncture, and patients in the control group were treated by acupuncture. Results: After the treatment, there was significant difference of therapeutic effect between two groups on the degree of improving functional defects (P<0.05), and the treatment group showed better results. Conclusion: Mental intervention and acupuncture treating stroke patients with dysthymic disorder could increase the treatment effect, reduce the disability ratio, and bring patients back to their family and the society.