To observe the clinical efficacy of moxibustion in the treatment of hemodialysis hypotension．Methods: Seventy one maintenance hemodialysis patients were randomly divided into a treatment group (n=37) and a control group (n=34), and routine western medicines were used in both groups. Besides, moxibustion was given at acupoints of Zúsānlǐ, Sānyīnjiāoand Guānyuán with a paper-tube-moxibustion equipment in the treatment group. The hypotension incidence relevant to dialysis, symptomatic hypotension, and curative effect of the two groups were compared and evaluated. Results: On the 3rd period of treatment course, the incidence of low blood pressure of the treatment group was lower than that of the control group (P<0.05), and the differences continued until 2 months after follow-up; the incidence of symptomatic hypotension of the treatment group was lower than the control group in follow-up and treatment period, and the difference was statistically significant (P<0.05). Conclusion: The moxibustion could prevent the occurrence of the blood dialysis hypotension with slow but long-lasting effect. At the same time, it could enhance patients’ tolerance in the process of hemodialysis, so as to reduce the occurrence of symptomatic hypotension.