To investigate the clinical efficacy and safety of acupuncture along with manipulation on knee after artificial knee replacement surgeries. Methods: One hundred and ten patients were randomized with the proportion of 1:1 into two groups. Patients in the control group were given conventional rehabilitation guidance and CPM mechanical training, and patients in the observation group received extra acupuncture with manipulation on the knee. HSS score, knee function, clinical efficacy and safety were compared. Results: After one course of treatment, compared with the data before treatment, the HSS score, maximum flexion, range of motion, and VAS scores of both groups were significantly different (P<0.05), and the degree of improvement in observation group was better (P<0.05); the total curative rate of the observation group was 83.64%, and that of the control group was 70.91%, and the difference of the excellent rates between the two groups was statistically significant (Ridit z=12.353,P=0.000); the follow-up showed that the incidence of complications was 1.82% in the observation group, and it was 7.27% in the control group, which showed statistically significant difference (χ2=24.587,P=0.000). Conclusion: Acupuncture along with manipulation on knee treating stiffness and pain after knee replacement surgery has significant effect and safety, and it is worthy of clinical application.