Latest reports showed that chronic inflammation is an important factor leading to tumors. Chronic inflammation of the colon and rectum would lead to repeated damage, repair and proliferation of the local tissues in inflammation area, and eventually cause cancer. Therefore, finding out how to intervene the chronic inflammation so as to decrease the occurrence of colorectal cancer has become an important method. This article explored the effects of purslane on intestinal inflammation, occurrence and development of tumor, as well as its relation to IL-6/STAT3 pathway. It provided new research ideas to the prevention of inflammatory bowel diseases.