To investigate the outcome of degenerative lumbar canal stenosis treated with Yaobi granules. Methods: Totally 175 cases were separated randomly into Treatment Group (92 cases treated with Yaobi granules) and Control Group B (83 cases treated with Glucosamine Indomethacin entric-coated tablets). The outcome of 2-week treatment and 6-week follow up were appraised by the JOA criteria and the neurogenic claudication by pedometer. Results: Treatment Group demonstrated better effect than the Control Group. Treatment Group had an effective rate of 86.8% and excellent rate of 54.5% and showed a significant difference (P=0.001) compared with the Control Group (effective rate 58.8% and excellent rate 23.8%). Apart from footsteps, walking distance, time and speed also improved significantly in treatment Group than that in the Control Group (P<0.05). During the 6-week follow-up, results were similar as above. Conclusion: Yaobi granules showed positive effect in treating degenerative lumbar canal stenosis and in enhancing walking ability of patients.