To observe the clinical efficacy of traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis. Methods: Eighty-four patients with knee osteoarthritis were randomly divided into control group and treatment group. Control group received simple sodium hyaluronate intra-articular injection therapy, and the treatment group was additionally given Chinese medicine XI TONG NING heat vaporization therapy. Results: The total effective rate was 69.0% in the control group and 90.5% in the treatment group. The difference was statistically significant (P<0.05). In treatment group, the scores of VAS and WOM- AC were improved after treatment (P<0.05). In control group, however, only VAS score declined further (P<0.05). Conclusion: The clinical effect of XI TONG NING combined with sodium hyaluronate is significant, thus it is suggested to be widely used in the treatment of knee osteoarthritis clinically.