To sum up the experience of Professor Li Shizeng on the treatment of chronic gastritis. Methods: By collecting a large number of cases of chronic gastritis treated by Professor Li Shizeng, this paper summarized his treatment methods on chronic gastritis, and evaluated the treatment efficacy through the means of clinical observation. Results: Professor Li Shizeng often applies five treatment methods, namely clearing heat, harmonization, moistening, supplement and invigorating blood, combining pattern differentiation with disease differentiation. Conclusion: Professor Li Shizeng has accumulated rich clinical experience about the treatment of chronic gastritis and has achieved satisfactory clinical efficacy.