To investigate the effects of Panax notoginseng saponins (PNS) on the cerebral edema and thrombin in the rats with cerebral hemorrhage (ICH).Methods: In present study, 200 SD rats were randomly divided into 4 groups: blank control, sham control, model and PNS treatment groups. ICH was induced by stereotactic injection of the collagenase Ⅳinto the right caudate nucleus. PNS or saline was injected intraperitoneally once a day after ICH, and the neurologic impairment was assessed by nMSS method for 5 time points: 6 h, 24 h, 48 hour, 72 h and 7 d. Both content of serous fibrinogen (FIB) and Fibrinogen clotting time (FIBs) were measured. Results: The score of mNSS increased from 6h (P<0.05) following ICH, and peaked at 48h, then returned to the normal on the 7th day, and the PNS decreased cerebral water content significantly at every examined time points except for 6 h (P<0.05). Moreover, both serous FIB and FIBs increased obviously at 48 h after ICH (P<0.05). The PNS inhibited the increase of both content compared with that in model group (FIB P=0.017, TT P=0.028).Conclusion: In rats, the score of mNSS started from 6h following ICH with a peak at 48 hours, and then decreased gradually, accompanied by the elevation of FIB and FIBs at 48h. PNS can effectively alleviate the score of mNSS via the inhibition of coagulation cascade pathway.