To optimize the alcohol extraction process of GuSong QiangGu Granule. Methods:Orthogonal test was employed for selecting the optimum of alcohol extraction process by the indexes of the contents of ginsenoside Rg1 and total solid matters. Results: Ten times amount of 70% ethanol concentration, extracting 3 times with 1.5 hours for each time was considered the optimum alcohol extraction process of Gusonng Qianggu Granule. Conclusion: The optimum alcohol extraction process condition was stable and feasible.