To evaluate the gastrointestinal adverse reactions induced by aspirin and/or clopidogrel in patients with stable coronary heart disease (CHD). Methods：A prospective cohort study was designed using gastrointestinal adverse reaction questionnaire. After a preliminary investigation and consummating the questionnaire，the gastrointestinal adverse reactions of stable coronary heart disease (CHD) patients conforming to the criteria (having a history of myocardial infarction or coronary angiography examination showing at least a coronary artery stenosis 50% or higher and no obvious symptoms of angina pectoris nearly three months) were observed. The patients were divided into single-antiplatet group (aspirin or clopidogrel only) and dual-antiplatet group according to whether patients used aspirin and/or clopidogrel. We had one follow-up every 3 months for 1 year，using the outpatient service and telephone follow-up. We Observed and recorded the endpoint and gastrointestinal adverse reaction. The incidence and degree of gastrointestinal adverse reactions using chi-square were analyzed. Results：A total number of 1099 cases of patients met the inclusion criteria，including 401 cases of single-antiplatet group and 698 cases of dual-antiplatet group. There was no significant difference between both groups on sex，age，CHD history，complicating disease，aspirin medication history，clopidogrel medication history and digestive tract symptoms. There was no significant difference between single-antiplatelet group and dual-antiplatelet group in the incidence of nausea or vomiting，stomachache or gastric stuffiness，abdominal distension heartburn or abdominal pain at the same time（P>0.05）. At the sixth and twelfth month of follow-up，compared with the single-antiplatet group，the incidence rate of pantothenic acid heartburn of dual- antiplatet was significantly higher（P<0.05，P<0.01. At the sixth and twelfth month of follow-up，compared with the single-antiplatet group，the overall incidence rate of gastrointestinal adverse reactions and gastrointestinal adverse reactions credits of dual- antiplatet group was significantly higher too（P<0.05，P<0.01）. There was no statistical difference between two groups of the end index (P> 0.05).Conclusion：Long-term usage of antiplatelet drugs aspirin and clopidogrel can cause gastrointestinal adverse reactions higher than application of aspirin or clopidogrel only.